观看视频，请点击：http://mooc.chaoxing.com/nodedetailcontroller/visitnodedetail?knowledgeId=2020307

报告人简介：
Z. Josh Huang博士目前是冷泉港实验室的Charles and Marie Robertson神经生物学教授。他在布兰迪斯大学（Brandeis University）获得细胞与分子生物学博士学位，并在麻省理工学院进行了博士后工作。他的长期研究目标是理解大脑皮层神经网络的发育装配和功能组织的基本机制。他率先通过系统性靶定特定细胞类型，将小鼠工程学应用于GABA能抑制性神经回路的遗传学解析。 他是生物医学领域的Pew Scholar奖和神经生物学的McKnight Scholar奖获得者，NARSAD脑和行为学研究基金会的特聘研究员，也是Simons基金会自闭症研究计划的Simon研究员。

Biography:
Dr. Z. Josh Huang is currently Charles and Marie Robertson Professor of Neuroscience at the Cold Spring Harbor Laboratory in New York.

He received his PhD in Cell and Molecular Biology at Brandeis University and his postdoctoral training at Massachusetts Institute of Technology.

His long term research goal aims to understand the basic mechanisms underlying the developmental assembly and function organization of neural circuits in the cerebral cortex. He has pioneered the use of mouse engineering toward a genetic dissection of GABAergic inhibitory circuitry by systematically targeting distinct cell types.

He is the recipient of Pew Scholar Award in Biomedical Science, McKnight Scholar Award in Neuroscience, Distinguished Investigator of NARSAD-Brain and Behavior Research Foundation, and Simon’s Investigator of Simons Foundation AutismResearch Initiative.

报告摘要：
哺乳动物大脑皮层由一群相互联系的脑区构建而成，包含多种环路模块，由此产生了广泛的精神活动。理解皮层结构信息的主要障碍包括细胞类型的多样化、局部和整体连接活动的高度复杂性、动态的回路活动以及由基因组决定的发育装配过程。随着我们关于基因表达和发育遗传法则的知识增多，通过系统性地靶定细胞类型及神经祖细胞世系追踪等，使得对皮层回路进行遗传学解析成为可能。战略性地构建一定数目的小鼠驱动品系有利于编制细胞类型信息表，构建皮层细胞图谱，建立现代实验工具。将细胞分辨率和全脑尺度的光电成像技术相结合，可在细胞和细胞类型分辨率水平对海量信息处理机制进行系统性研究。

Abstract:
The mammalian neocortex gives rise to a wide range of mental activities and consists of a constellation of interconnected cortical areas, built from variations of a set of basic circuit templates. Major obstacles to understanding cortical architecture include the stunning diversity of cell types, their highly recurrent local and global connectivity, dynamic circuit operations, and a convoluted development assembly process rooted in the genome. With our increasing knowledge of gene expression and developmental genetic principles, it is now feasible to launch a genetic dissection of cortical circuits through systematic targeting of cell types and fate-mapping of neural progenitors. Strategic design of a modest number of mousedriver lines will facilitate efforts to compile a cell type parts list, build a cortical cell atlas, establish experimentalaccess to modern tools. Combined with cell resolution and brain-wide optoelectronic imaging, it is opportune to systematically discover the myriad of information processing streams and communication channels with cellular and cell type resolution.